FLT3-ITD [D835del]/BaF3
CBP73241
詢 價
留 言
產品描述
產品數(shù)據(jù)庫
| I. Introduction | |
|
Cell Line Name： |
FLT3-ITD [D835del]/BaF3 |
|
Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
|
Freeze Medium: |
90% FBS+10% DMSO
|
|
Complete Culture Medium: |
RPMI-1640+10%FBS+2ug/ml puromycin
|
|
Mycoplasma Status: |
Negative |
| II. Background | |
|
FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385). |
|
| III. Representative Data | |
|
1.FLT3-ITD [D835del]/BaF3
|
|
|
2. Anti-proliferation assay
Figure . Anti-proliferation assay of three reference compounds on the FLT3-ITD [D835del]/BaF3 Stable Cell Line. |
|
