hENPP3/4T1
CBPG0211
詢 價
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Background | |||
| ENPP3 基因（又稱 CD203c 或 NPP3）位于人類染色體 6q23.2-q23.3 區(qū)域，編碼一種Ⅱ 型跨膜蛋白，屬于外核苷酸焦磷酸酶/磷酸二酯酶（ENPP）家族。ENPP3 的核心功能包括 水解細(xì)胞外核苷酸（如 ATP、GTP、UTP、CTP）和磷酸二酯鍵，調(diào)節(jié)嘌呤能信號傳導(dǎo)。 它通過消除細(xì)胞外 ATP（一種觸發(fā)炎癥細(xì)胞因子釋放的信號分子）來抑制慢性過敏和炎癥 反應(yīng)中肥大細(xì)胞及嗜堿性粒細(xì)胞的活化。此外，ENPP3 還具有磷脂酶 D 樣活性，參與磷脂 酰膽堿的水解，生成磷脂酸和膽堿，影響膜重塑和囊泡運輸?shù)燃?xì)胞過程。ENPP3 通過其多 酶活性和廣泛的生物學(xué)功能，在骨骼代謝、免疫調(diào)節(jié)、癌癥進展及過敏反應(yīng)中發(fā)揮重要作 用，成為具有潛力的治療靶點。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hENPP3 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+ 10 μg/ml Blasticidin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
IV. Representative Data Figure1.Recombinant hENPP3/4T1 stably expressing hENPP3. |
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